The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 11, 2005

Filed:

Oct. 01, 1999
Applicants:

Nasser Chegini, Gainesville, FL (US);

James Burns, Watertown, MA (US);

Michael P. Diamond, Grosse Pointe, MI (US);

Lena E. Holmdahl, Cambridge, MA (US);

Inventors:

Nasser Chegini, Gainesville, FL (US);

James Burns, Watertown, MA (US);

Michael P. Diamond, Grosse Pointe, MI (US);

Lena E. Holmdahl, Cambridge, MA (US);

Assignees:

University of Florida, Gainesville, FL (US);

Wayne State University, Detroit, MI (US);

Genzyme Corporation, Framingham, MA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39395 ; A61K 3944 ; C07K 1628 ;
U.S. Cl.
CPC ...
Abstract

Methods for the prevention of adhesion formation involve the administration of therapeutic formulations to a patient which include antibodies to TIMP-1 or TIMP-1 antisense oligonucleotides. The formulations can also include suitable carriers, such as a hyaluronic acid matrix, for optimal administration. The treatment procedure can be initiated and monitored by a diagnostic procedure which involves the detection of elevated levels of TIMP-1 in a patient.


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