The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 04, 2005
Filed:
May. 28, 2003
Applicant:
Kevin J. Tracey, Old Greenwich, CT (US);
Inventor:
Kevin J. Tracey, Old Greenwich, CT (US);
Assignee:
North Shore-Long Island Jewish Research Institute, Manhasset, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 3144 ; A61K 3134 ; A61K 3122 ;
U.S. Cl.
CPC ...
Abstract
A method of inhibiting the release of a proinflammatory cytokine in a cell is disclosed. The method comprises treating the cell with a cholinergic agonist. The method is useful in patients at risk for, or suffering from, a condition mediated by an inflammatory cytokine cascade, for example endotoxic shock. The cholinergic agonist treatment can be effected by stimulation of an efferent vagus nerve fiber, or the entire vagus nerve.