The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 04, 2005
Filed:
Nov. 29, 2001
Hans Ulrich Stilz, Frankfurt, DE;
Volkmar Wehner, Sandberg, DE;
Christoph Huls, Wackernheim, DE;
Dirk Seiffge, Mainz-Kostheim, DE;
Hans Ulrich Stilz, Frankfurt, DE;
Volkmar Wehner, Sandberg, DE;
Christoph Huls, Wackernheim, DE;
Dirk Seiffge, Mainz-Kostheim, DE;
Aventis Pharma Deutschland GmbH, Frankfurt am Main, DE;
Abstract
The present invention relates to compounds of the formula Iwhich are inhibitors of the adhesion and migration of leucocytes and/or antagonists of the adhesion receptor VLA-4 which belongs to the group of integrins. The invention also relates to processes for the preparation of formula I, pharmaceutical compositions containing compounds of formula I, and the treatment or prophylaxis of various diseases caused by or are associated with excess leucocyte adhesion and/or leucocyte migration, as well as diseases associated with cell-cell or cell-matrix interactions, which on interactions of VLA-4 receptors with their ligands play a part of, for example, inflammatory processes, rheumatoid arthritis or allergic disorders.