The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 04, 2005
Filed:
Apr. 02, 1999
Michael Derek Roth, Los Angeles, CA (US);
Robert Alan Figlin, Los Angeles, CA (US);
Sylvia Marie Kiertscher, Los Angeles, CA (US);
Barbara Jennifer Gitlitz, Los Angeles, CA (US);
Michael Derek Roth, Los Angeles, CA (US);
Robert Alan Figlin, Los Angeles, CA (US);
Sylvia Marie Kiertscher, Los Angeles, CA (US);
Barbara Jennifer Gitlitz, Los Angeles, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
The present invention provides methods for enhancing the development of APC from precursor cells by administering a combination of GM-CSF and IL-4. The precursor cells include: cells contained in peripheral blood, CDcells and precursors in bone marrow. Thus, administration of GM-CSF and IL-4 can be used as a form of cytokine immunotherapy. One embodiment of the present invention involves systemic administration of GM-CSF and IL-4. In this embodiment, APC are required to directly access tumor antigens as they exist in vivo within the patient. A further embodiment of the present invention involves co-administration of a tumor-associated or tumor-specific antigen, with GM-CSF and IL-4, to induce antigen-specific immunity mediated by APC. Yet another embodiment of the present invention describes systemic administration of GM-CSF and IL-4 to achieve reduced tumor burden.