The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 21, 2004
Filed:
Jul. 24, 2001
Gerrit Klaerner, Campbell, CA (US);
Ralph B. Nielsen, San Jose, CA (US);
Paul Mansky, San Francisco, CA (US);
Didier Benoit, San Jose, CA (US);
Dominique Charmot, Los Gatos, CA (US);
Bernd Jandeleit, Sunnyvale, CA (US);
Laura T. Mazzola, Redwood City, CA (US);
Symyx Technologies, Inc., Santa Clara, CA (US);
Abstract
Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, and in particular the use of an iniferter initiator, which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.