The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 21, 2004
Filed:
Oct. 19, 2001
Applicant:
Inventors:
James Travis, Athens, GA (US);
Jan S. Potempa, Athens, GA (US);
Daniel C. Nelson, New York, NY (US);
Assignee:
University of Georgia Research Foundation, Inc., Athens, GA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/52 ; C12N 1/257 ; C12N 1/270 ; C12N 1/274 ; C12Q 1/37 ;
U.S. Cl.
CPC ...
C12N 9/52 ; C12N 1/257 ; C12N 1/270 ; C12N 1/274 ; C12Q 1/37 ;
Abstract
An isolated oral bacterial polypeptide having amidolytic activity for cleavage of denatured polypeptides and nondenatured serpin polypeptides and particularly a human &agr; -proteinase inhibitor polypeptide is provided. The mature polypeptide of the invention has a molecular weight of about 70 kD to about 80 kD. Also provided is an isolated nucleic acid sequence encoding the oral bacterial polypeptide of the invention, methods for identifying inhibitors of the polypeptide and compositions such as immunogenic compositions and inhibitor compositions.