The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 07, 2004
Filed:
Nov. 01, 2001
Applicant:
Inventors:
Martyn Frank Burslem, County of Kent, GB;
Ian Dennis Harrow, County of Kent, GB;
Jeremy Lanfear, County of Kent, GB;
Stephen Charles Phillips, County of Kent, GB;
Assignee:
Pfizer Inc., New York, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A01K 6/7027 ; C12N 5/00 ; C12N 5/02 ; C12N 5/06 ; C12N 5/10 ;
U.S. Cl.
CPC ...
A01K 6/7027 ; C12N 5/00 ; C12N 5/02 ; C12N 5/06 ; C12N 5/10 ;
Abstract
The invention provides genetically-modified non-human mammals and genetically-modified animal cells containing a functionally disrupted PDE11A gene. Also provided by the invention are methods of screening for agents that modulate PDE11A to modulate spermatogenesis, methods of treating mammals to modulate spermatogenesis, and methods of modulating cAMP and cGMP signal transduction in cells that express PDE11A.