The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 07, 2004
Filed:
Aug. 21, 2001
Applicant:
Inventors:
Daniela Santoli, Bryn Mawr, PA (US);
Giovanni Rovera, Bryn Mawr, PA (US);
Alessandra Cesano, Newburt Park, CA (US);
Assignee:
The Wistar Institute of Anatomy and Biology, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/00 ; C12N 5/02 ; C12N 5/08 ;
U.S. Cl.
CPC ...
C12N 5/00 ; C12N 5/02 ; C12N 5/08 ;
Abstract
TALL-104 cells, and other cytotoxic T cell lines, may be modified to increase the cytotoxicity thereof, to enhance growth properties, and/or to provide a preferred phenotype, e.g., expression of cell surface antigens, function, e.g., change in cytokine production profile, by culturing the cells in an effective amount of IL-15, optionally followed by gamma irradiation to halt proliferation.