The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 23, 2004
Filed:
Oct. 08, 2002
Applicant:
Inventors:
Eric L. Williams, Zachary, LA (US);
Tse-Chong Wu, Baton Rouge, LA (US);
Assignee:
Albemarle Corporation, Richmond, VA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07L 6/500 ;
U.S. Cl.
CPC ...
C07L 6/500 ;
Abstract
Roflumilast and new key intermediates therefor are prepared by processes involving use of carbonylation technology. Good overall yields can be achieved using available starting materials. The starting material for the process can be catechol, an o-R -phenol, an o-R -p-X-phenol, or a 1-X-3-R -4-R -benzene, where R , is a C alkoxy, C cycloalkoxy, C cycloalkylmethoxy, or benzyloxy group, or a C alkoxy group which is completely or partially substituted by fluorine; R is a C alkoxy group which is completely or partially substituted by fluorine; and X is Cl, Br, or I.