The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 16, 2004
Filed:
Jun. 03, 2003
Shozo Yamada, Hanno, JP;
Kazuhiko Shigeno, Iruma, JP;
Kazuhiro Kitagawa, Hanno, JP;
Shigeo Okajima, Tokorozawa, JP;
Tetsuji Asao, Kokubunji, JP;
Other;
Abstract
A method of manufacturing substance GM-95 having general formula [I], comprising (a) deprotecting a macrocyclic compound having general formula [II] (wherein, R 's are the same or different and each represents a lower alkyl group, and R represents a thiol protecting group) by removing acetal protecting groups (the R 's) thereof, and forming an oxazole ring through an intramolecular cyclization reaction between produced formyl group and an amide group, and (b) deprotecting a resulting macrocyclic compound having general formula [III] (wherein, R is as mentioned above) by removing the thiol protecting group (R ) thereof, and forming a thiazoline ring through an intramolecular cyclization reaction between a thiol group thus produced and an amide group.