The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 09, 2004
Filed:
Jun. 03, 2002
Nándor Makk, Kismaros, HU;
Gábor Ambrus, Budapest, HU;
Anikó Tegdes, Budapest, HU;
András Jeney, Telki, HU;
Ferenc Timár, Budapest, HU;
IVAX International GmbH, Rapperswil, CH;
Abstract
The invention relates to compounds of general formula (I) wherein R stands for a group of general formula —COOR , —CONR R , —CONR CONR R or —CH OR , wherein R stands for a C alkyl group; a C alkyl group substituted; or a C cycloalkyl group; R and R are identical or different and stand independently from each other for hydrogen atom or a C alkyl group which optionally may be substituted; a 5- or 6-membered cycloalkyl or a heteroaryl group; and their tautomers, solvates and the mixtures thereof and acid addition salts of these compounds. The invention also relates to pharmaceutical compositions comprising compounds of general formula (I) as active agent. The angiogenesis-inhibitors according to the invention inhibit the neovascularization in living tissues and as such can be used for preventing and inhibiting angiogenesis appearing in connection with tumor growth and for preventing the formation of tumor metastases.