The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 09, 2004
Filed:
Jun. 06, 2003
Sung-Bo Ko, Taejon, KR;
Eu-Gene Oh, Taejon, KR;
Eon-Kyeom Kim, Taejon, KR;
Won-Yeob Kim, Taejon, KR;
Dennis W. Choi, St. Louis, MO (US);
Laura L. Dugan, St. Louis, MO (US);
Jae-Young Koh, Seoul, KR;
Moo-Ho Won, Chuncheon, KR;
Myung-Bok Wie, Chuncheon, KR;
Sam-Sung Electronics Co., Ltd., Suwon, KR;
Abstract
The present invention provides novel seleno compounds containing nitrone moiety, a process for preparing the same, the use of the novel compounds as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen species, in particular stroke, Parkinson's disease, Alzheimer's disease. The compounds of the invention have similar or superior lipid peroxidation (LPO) inhibition activity to the reference compounds. While showing lower toxicity and better water solubility, they also effectively inhibit the cerebral neuronal cell death caused by ROS and show neuroprotective effects against ischemic neuronal degeneration.