The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 09, 2004
Filed:
May. 25, 1999
Applicant:
Inventors:
Geoffrey M. Thiele, Omaha, NE (US);
Thomas L. McDonald, Omaha, NE (US);
Dean J. Tuma, Omaha, NE (US);
Lynell W. Klassen, Omaha, NE (US);
Michael F. Sorrell, Omaha, NE (US);
Assignee:
The Board of Regents of the University of Nebraska, Lincoln, NE (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 4/900 ; A61B 1/000 ; G01N 3/3564 ; C07D / ;
U.S. Cl.
CPC ...
A61K 4/900 ; A61B 1/000 ; G01N 3/3564 ; C07D / ;
Abstract
A novel protein adduct is disclosed which is associated with the presence of alcohol liver disease. The adduct is a hybrid product of malondialdehyde and acetaldehyde which act synergistically to bind hepatic proteins. The adduct is highly immunogenic and fluorescent. Methods of detection are also disclosed including monoclonal and polyclonal antibodies.