The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 02, 2004
Filed:
Nov. 07, 2002
Scott Douglas Cowen, Longport, CO (US);
Paul David Greenspan, New Providence, NJ (US);
Leslie Wighton McQuire, Warren, NJ (US);
Ruben Alberto Tommasi, Whitehouse Station, NJ (US);
John Henry Van Duzer, Georgetown, MA (US);
Novartis AG, Basel, CH;
Abstract
Compounds of the formula (I), wherein R is aryl or biaryl; R is aryl-lower alkyl, biaryl-lower alkyl, benzo-fused cycloalkyl, cycloalkyl-lower alkyl, bicycloalkyl-lower alkyl, aryloxy-lower alkyl, or aryl-C -C -alkyl in which C -C -alkyl is interrupted by Y; Y is O, S, SO, SO , CO or NR ; R is hydrogen or lower alkyl; or R and R combined are C -C -alkylene or C -C -alkylene interrupted by Y; R is hydrogen or lower alkyl; R is hydrogen, optionally substituted lower alkyl, aryl-lower alkyl, biaryl-lower alkyl, cycloalkyl-lower alkyl, bicycloalkyl-lower alkyl, aryloxy-lower alkyl, or aryl-C -C -alkyl in which C -C -alkyl is interrupted by Y; R is hydrogen, lower alkyl or aryl-lower alkyl; and pharmaceutically acceptable salts thereof, which are useful as cysteine cathepsin inhibitors