The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 19, 2004
Filed:
Apr. 18, 2002
Applicant:
Inventors:
J. Fraser Glickman, Basel, CH;
James Inglese, Lansdale, PA (US);
Bassam Damaj, San Diego, CA (US);
Maria L. Webb, Flemington, NJ (US);
Jonathan J. Burbaum, San Diego, CA (US);
Assignee:
Pharmacopeia Drug Discovery, Inc., Cranbury, NJ (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 3/3567 ; G01N 3/3566 ;
U.S. Cl.
CPC ...
G01N 3/3567 ; G01N 3/3566 ;
Abstract
A method for determining the level of tyrosine kinase activity in a biological sample is disclosed. The method employs an anti-phosphotyrosine antibody as both the capture agent and the detecting agent. The detecting antibody is labeled with a fluorescent label, for instance, Cy5, Cy5.5 or Cy7 or a lanthanide ion, such as europium, as the signal generating entity. The method is particularly well suited to high throughput screening, for example, for compounds which modulate tyrosine kinase activity.