The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 05, 2004
Filed:
Jun. 15, 2001
Applicant:
Inventors:
Claude Négrier, Irigny, FR;
Jean Luc Plantier, Grigny, FR;
Assignee:
Aventis Behring GmbH, Marburg, DE;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P 2/104 ; C12N 5/00 ; C12N 1/563 ; C07H 2/104 ;
U.S. Cl.
CPC ...
C12P 2/104 ; C12N 5/00 ; C12N 1/563 ; C07H 2/104 ;
Abstract
A modified Factor VIII cDNA is described in which the B-domain of the wild-type Factor VIII cDNA has been deleted and a truncated Factor IX intron 1 has been inserted in one or more locatons of the Factor VIII cDNA. Such modified Factor VIII cDNA may be used for a higher yield production of Factor VIII in vitro as well as in a transfervector for gene therapy.