The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 28, 2004
Filed:
Dec. 13, 2000
Applicant:
Inventors:
Dinesh Patel, Fremont, CA (US);
Jeffrey W. Jacobs, San Mateo, CA (US);
Rakesh Jain, Fremont, CA (US);
Zhi-Jie Ni, Fremont, CA (US);
Zhengyu Yuan, Fremont, CA (US);
Assignee:
Vicuron Pharmaceuticals Inc., Fremont, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/15377 ; A61K 3/14025 ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
A61K 3/15377 ; A61K 3/14025 ; C07D / ; C07D / ;
Abstract
Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The hydroxymates are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as matrix metalloproteinases (MMPs). Methods of synthesis and of use of the compounds are also disclosed.