The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 31, 2004
Filed:
Nov. 13, 2001
The Florida International University Board of Trustees, Miami, FL (US);
Abstract
A device and method of detecting surface plasmon resonance for sensing molecules or conformational changes in molecules with high resolution and fast response time is disclosed. Light from a light source ( ) is focused through a prism onto a metal thin film ( ) on which sample molecules to be detected are adsorbed. The total internal reflection of the laser/incident light is collected with a differential position or intensity sensitive photo-detecting device instead of a single cell or an array of photo-detectors ( ) that are widely used in previous works. The ratio of the differential signal to the sum signal of the differential position or intensity sensitive photo-detecting device ( ) provides an accurate measurement of the shift in the surface plasmon resonance angle caused by the adsorption of molecules onto the metal films ( ) or by conformational changes in the adsorbed molecules. The present invention requires no numerical fitting to determine the resonant angle and the setup is compact and immune to background light, The methods and sensors of this invention can be used in numerous biological, biochemical, and chemical applications such as measuring subtle conformational changes in molecules and electron transfer reactions can be studied.