The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 31, 2004
Filed:
May. 04, 2001
Applicant:
Inventors:
Patrick L. Iversen, Corvallis, OR (US);
Robert Hudziak, Blodgett, OR (US);
Assignee:
AVI BioPharma, Inc., Corvallis, OR (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 2/104 ; C12Q 1/68 ; C12P 1/934 ;
U.S. Cl.
CPC ...
C07H 2/104 ; C12Q 1/68 ; C12P 1/934 ;
Abstract
Antisense compositions targeted against an mRNA sequence coding for a selected protein, at a region having its 5′ end from 1 to about 25 base pairs downstream of a normal splice acceptor junction in the preprocessed mRNA, are disclosed. The antisense compound is RNase-inactive, and is preferably a phosphorodiamidate-linked morpholino oligonucleotide. Such targeting is effective to inhibit natural mRNA splice processing, produce splice variant mRNAs, and inhibit normal expression of the protein.