The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 24, 2004
Filed:
Aug. 14, 2001
Roelof Feenstra, Weesp, NL;
Johannes A. M. Van Der Heijden, Weesp, NL;
Cornelis G. Kruse, Weesp, NL;
Stephen K. Long, Weesp, NL;
Johannes Mos, Weesp, NL;
Gerben M. Visser, Weesp, NL;
Gustaaf J. M. Van Scharrenburg, Weesp, NL;
Gerrit P. Toorop, late of Weesp, NL;
DUPHAR International Research BV, Weesp, NL;
Abstract
The invention relates to a group of novel piperazine and piperidine derivatives of formula (I), wherein: S is hydrogen, halogen, alkyl (1-3C), CN, CF , OCF , SCF , alkoxy (1-3C), amino or mono- or dialkyl (1-3C) substituted amino, or hydroxy; X represents NR , S, CH , O, SO or SO , wherein R is H or alkyl (1-3C); . . . Z represents ═C or —N; —R independently represent H or alkyl (1-3C), or R and R together can form a bridge 2 or 3 C-atoms; R is hydrogen or alkyl (1-3C); Q is methyl, ethyl, ethyl substituted with one or more fluorine atoms, cyclopropyl—methyl, optionally substituted with one or more fluorine atoms, and salts and prodrugs thereof. It has been found that these compounds have both partial dopamine D -receptor agonism and partial serotonin 5-HT -receptor agonism mediated activities.