The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 2004
Filed:
Jun. 20, 2002
Applicant:
Inventors:
James Michael Wardleworth, Macclesfield Cheshire, GB;
Francis Thomas Boyle, Macclesfield Cheshire, GB;
Zbigniew Matusiak, Macclesfield Cheshire, GB;
Assignee:
AstraZeneca AB, Sodertalje, SE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/140 ; C07D / ;
U.S. Cl.
CPC ...
A61K 3/140 ; C07D / ;
Abstract
This invention relates to compounds of formula (I) that inhibit farnesylation of gene products through inhibition of the enzyme farnesyl-protein transferase (FPTase). The invention also relates to methods of manufacturing the compounds, pharmaceutical compositions and methods of treating diseases, especially cancer, which are mediated through farnesylation.