The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 10, 2004
Filed:
Oct. 26, 2000
Applicant:
Inventors:
Harold A. Chapman, San Francisco, CA (US);
Guo-Ping Shi, San Francisco, CA (US);
Peter Libby, Boston, MA (US);
Galina K. Sukhova, Swampscott, MA (US);
Daniel I. Simon, Waban, MA (US);
Assignee:
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 3/816 ; A61K 3/802 ; A61K 3/846 ; C07K 1/400 ;
U.S. Cl.
CPC ...
A61K 3/816 ; A61K 3/802 ; A61K 3/846 ; C07K 1/400 ;
Abstract
The invention provides methods of treating and preventing vascular diseases, by inhibiting cysteine proteases active at sites of vascular injury, particularly cathepsins K and S, by administering cystatin C or TGF-&bgr; . Cystatin C is severely reduced in both atherosclerotic and aneurysmal aortic lesions. Also provided is a method of diagnosing a patient at risk of, or with, vascular injury by detecting low levels of circulating cystatin C.