The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 10, 2004
Filed:
Jul. 20, 2001
Robert M. Winslow, La Jolla, CA (US);
Kim D. Vandegriff, San Diego, CA (US);
Sangart, Inc., San Diego, CA (US);
Abstract
The invention relates to a system and a method of using an automated blood cell separator to prepare a high-quality hemoglobin solution as the raw material for manufacture of hemoglobin-based therapeutic oxygen carriers, so-called “blood substitutes”. The method of isolating stroma-free hemoglobin comprises the steps of: separating the red blood cells from the starting solution; washing the red blood cells in wash solution; contacting the red blood cells with a hypotonic solution to produce stromata and a hemolysate containing hemoglobin having an ionic strength and separating the hemolysate from the stromata. Further, the invention relates to a method for preparing a chemically modified hemoglobin solution. This method comprises the steps of: separating the red blood cells from the staring solution; washing the red blood cells in wash solution; contacting the red blood cells with a hypotonic solution to produce stromata and a hemolysate containing hemoglobin having an ionic strength; separating the hemolysate from the stromata; and mixing the hemolysate with a reagent adapted to chemically modify the hemoglobin to form a chemically modified hemoglobin solution.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile