The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 03, 2004
Filed:
Jul. 14, 2000
Applicant:
Inventors:
Manish Aghi, Brookline, MA (US);
Christof M. Kramm, Duesseldorf, DE;
Xandra O. Breakefield, Newton, MA (US);
Assignee:
The General Hospital Corporation, Boston, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 3/170 ; A61K 4/800 ; C12N 1/563 ; C12N 1/587 ; C12N 1/586 ;
U.S. Cl.
CPC ...
A61K 3/170 ; A61K 4/800 ; C12N 1/563 ; C12N 1/587 ; C12N 1/586 ;
Abstract
Methods of killing neoplastic cells are provided. The invention relates to the use of folylpolyglutamyl synthetase (FPGS) gene transfer to enhance the sensitivity of several types of tumor cells to polyglutamylatable antifolate drugs, such as methotrexate (MTX) and edatrexate (EDX).