The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 03, 2004
Filed:
Mar. 07, 2001
Richard Wa Luke, Macclesfield, GB;
Philip J. Jewsbury, Macclesfield, GB;
Ronald Cotton, Macclesfield, GB;
AstraZeneca AB, Sodertalje, SE;
Abstract
A compound of formula (1), wherein: R is hydrogen, C alkyl, R CH — or R C(O)—; R is aryl, heteroaryl, heterocyclyl, aminoC alkyl, N-(C alkyl)aminoC alkyl, NN-(diC alkyl)aminoC alkyl, or R ; wherein the aryl, heteroaryl or heterocyclyl rings may be optionally substituted with up to three substituents independently selected from nitro, C alkyl, C alkoxy, halo, (C alkyl)sulfanyl, C alkoxycarbonyl, N-(C alkyl)carbamoyl, NN-(diC alkyl)carbamoyl, N-(C alkyl)amino or NN-(diC alkyl)amino; wherein R is either a group or formula (2) or formula (3); and wherein L , L , L , L , R , R , R , R , R , R , R , R , R , R , A , n, p, q, r and s are as defined herein. The compounds of formula (1) inhibit the interactions between MDM2 and p53 and may be useful in the treatment of cancers.