The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 03, 2004
Filed:
Nov. 27, 2000
Weon Kyoo You, Kyonggi-do, KR;
Seung Ho So, Taejon-si, KR;
Byung Cheul Ahn, Kyonggi-do, KR;
Hyosil Lee, Kyonggi-do, KR;
Soo-Il Jung, Kyonggi-do, KR;
Young jo Kim, Kyonggi-do, KR;
Jong Hyuk Lee, Seoul, KR;
Yong-Kil Hong, Seoul, KR;
Young Ae Joe, Seoul, KR;
Soo-Ik Chang, Chungcheongbuk-do, KR;
Korea Green Cross Corporation, Kyonggi-do, KR;
Abstract
The present invention relates to process of purifying the angiogensis inhibitor proteins expressed in and to the use of recombinant kringle 1-3 (; greenstatin) purified by the above process as a angiogenesis inhibitor and an anticancer agent. Particularly, according to the process of purifying the protein, the angiogenesis inhibitor proteins overexpressed are solubilized, refolded, and purified as a pure and active form. The greenstatin purified by the process specifically suppresses endothelial cell proliferation, anaiogenesis, and the growth of lung cancer, skin cancer, and brain tumor. Therefore, the process of this invention is applicable to the mass-production of angiogenesis inhibitor proteins such as greenstatin which is useful for the treatment of glaucoma, retinopathy, and cancers.