The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 13, 2004
Filed:
May. 16, 2001
John P. Peeters, Bethesda, MD (US);
Protiveris, Inc., Rockville, MD (US);
Abstract
A method for discovering proteins and protein geometries, and a method for conducting whole proteome assays on a single test surface are disclosed. A test surface is provided featuring a surface containing a random distribution of randomly shaped features of a size from 10 meters to 10 meters in width, height, depth, and spacing. A sample containing proteins is provided to interact with the test surface long enough for protein molecules to locate and adsorb to complementary sites on the test surface. Unadsorbed proteins are washed away. Protein adsorption sites are then discovered using a means such as an atomic force microscope (AFM) to identify locations where proteins are adsorbed to the surface. The topology of the protein adsorption sites is precisely measured using an AFM. Protein surface topology is deduced by determining the complementary surface to the protein adsorption sites. A device that is diagnostic for a disease is prepared by determining the disease-specific adsorption site pattern on a given test surface, in contrast to the non-disease pattern.