The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 06, 2004
Filed:
Jun. 29, 2001
Applicant:
Inventors:
Wen-Ghih Tsang, Sherman Oaks, CA (US);
Tianli Zheng, Culver City, CA (US);
Chang Jiang Huang, Los Angeles, CA (US);
Assignee:
AmCyte, Inc., Santa Monica, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 3/539 ; C12N 5/06 ; C12N 5/00 ; C12N 5/08 ;
U.S. Cl.
CPC ...
A61K 3/539 ; C12N 5/06 ; C12N 5/00 ; C12N 5/08 ;
Abstract
This invention relates to the discovery that an intermediate, differentiated stage of pancreatic stem cells exist that can be propagated in a stable manner in successive serial passaging while maintaining insulin production in response to glucose. These cells are advantageous in that they are both expandable and stable in culture and can driven to late stage development, i.e. prototype islet cells. This invention further provides for culturing techniques that select for these intermediate differentiated stage cells and selectively eliminates early or late stage pancreatic cells.