The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2004
Filed:
Apr. 10, 2000
Applicant:
Inventors:
Phillip Dan Cook, Escondido, CA (US);
Muthiah Manoharan, Carlsbad, CA (US);
Clarence Frank Bennett, Carlsbad, CA (US);
Assignee:
ISIS Pharmaceuticals, Inc., Carlsbad, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 2/104 ; A61K 4/800 ; C12Q 1/68 ;
U.S. Cl.
CPC ...
C07H 2/104 ; A61K 4/800 ; C12Q 1/68 ;
Abstract
The invention is directed to oligonucleotides and oligonucleosides functionalized to include lipophilic moieties and having improved biostability and altered biodistribution in mammals. In one embodiment, such lipophilic oligonucleotide conjugates are used in a method of targeting antisense oligonucleotides to hepatic tissues and thereby preferentially modulating gene expression in the liver and associated tissues of a mammal.
Quick Actions:
Cook, Phillip. (2004). Compositions and methods for enhanced biostability and altered biodistribution of oligonucleotides in mammals (U.S. Patent No. 6753423). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/6753423
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile