The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2004
Filed:
Sep. 19, 2000
Paolo Cozzi, Milan, IT;
Pier Giovanni Baraldi, Ferrara, IT;
Italo Beria, Villamarzana, IT;
Marina Caldarelli, Milan, IT;
Laura Capolongo, Milan, IT;
Romeo Romagnoli, Ferrara, IT;
Pharmacia & Upjohn S.p.A., Milan, IT;
Abstract
Compounds which are acryloyl substituted distamycin derivatives of formula (I) wherein: n is 2, 3 or 4; m is 1 or 2; X and Y are the same or different and are selected, independently for each heterocyclic ring of the polyetherocyclic chain, from N and CH; R and R , which are the same or different, are selected from hydrogen, halogen, and C -C alkyl; R is hydrogen or halogen; B is selected from (a), (b), (c), (d), (e), (f), (g) and —C≡N; wherein R , R , R , R , R , R , R , and R are, independently from each other, hydrogen or C -C alkyl; and R is hydrogen or hydroxy, or pharmaceutically acceptable salt thereof; provided that a) at least one of R , R and R is alkyl b) at least one of the heterocyclic rings within the polyheterocyclic chain is other than pyrole; and c) X and Y are not both N for the same heterocyclic ring; are useful as antitumor agents.