The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 08, 2004
Filed:
Apr. 18, 2001
Applicant:
Inventors:
David K. Ho, Walkersville, MD (US);
Raya Mandler, Bethesda, MD (US);
Ada Belinda Alvarado-Lindner, Frederick, MD (US);
Kaye B. Dillah Upadhyay, Gaithersburg, MD (US);
David J. Newman, Wayne, PA (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D / ; A61K 4/748 ; A61P 3/500 ;
U.S. Cl.
CPC ...
C07D / ; A61K 4/748 ; A61P 3/500 ;
Abstract
The present invention provides water-soluble drugs, in particular, water-soluble analogues of geldanamycin, and compositions comprising the same. This invention also provides a method of rendering water-soluble drugs soluble in water through derivatization with a bifunctional linking molecule and subsequent conjugation to a polar moiety through a thio ether. The present invention ether provides a method of treating cancer in a mammal.