The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 08, 2004
Filed:
Mar. 15, 2002
Eunice Eun-Kyeong Kim, Daejeon, KR;
Mi-Jeong Park, Daejeon, KR;
Tae-Hee Lee, Daejeon, KR;
Hye-Kyung Chang, Daejeon, KR;
Tae-Kyo Park, Daejeon, KR;
Chang-Yuil Kang, Seoul, KR;
Young-Myeong Kim, Chunchon, KR;
Kwang-Yul Moon, Daejeon, KR;
Young-Leem Oh, Daejeon, KR;
Chang-Hee Min, Daejeon, KR;
Hyun-Ho Chung, Daejeon, KR;
LG Chem Investment Ltd., Seoul, KR;
Abstract
The present invention provides to an isoxazoline derivative of formula (I), the pharmaceutically acceptable salts, esters and stereochemically isomeric forms thereof, and the use of the derivative in inhibiting the activity of caspases. The present invention also provides a pharmaceutical composition for preventing inflammation and apoptosis which comprise the isoxazoline derivative, pharmaceutically acceptable salts, esters and stereochemically isomeric forms thereof and the process for preparing the same. The derivative according to the present invention can be effectively used in treating diseases due to caspases, such as, for example the disease in which cells are abnormally died, dementia, cerebral stroke, AIDS, diabetes, gastric ulcer, hepatic injury by hepatitis, sepsis, organ transplantation rejection reaction and anti-inflammation.