The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 01, 2004
Filed:
Mar. 17, 1998
Applicant:
Inventor:
James M. Mason, Bethpage, NY (US);
Assignee:
North Shore University Hospital Research Corporation, Manhasset, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/5867 ; C12N 1/563 ; C12N 5/10 ; C12N 7/01 ;
U.S. Cl.
CPC ...
C12N 1/5867 ; C12N 1/563 ; C12N 5/10 ; C12N 7/01 ;
Abstract
The present invention relates to the use of non-primate mammalian cell lines having substantially no endogenous retroviral sequences as producer and packaging lines for preparation of human serum-resistant retroviral vector particles with improved safety for use in gene therapy applications. In a preferred embodiment, the cell line used in the present invention is the &agr;-galactosyl (&agr;Gal)-positive cell ferret brain cell line designated as Mpf or a cell line having those identifying characteristics of the Mpf cell line suitable for the practice of the invention.