The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 25, 2004
Filed:
Jun. 26, 2000
Applicant:
Inventors:
Avi J. Ashkenazi, San Mateo, CA (US);
Robert F. Kelley, San Bruno, CA (US);
Mark P. O'Connell, Montara, CA (US);
Robert M. Pitti, El Cerrito, CA (US);
Ralph A. Schwall, Pacifica, CA (US);
Assignee:
Genentech, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 1/4525 ; C07K 1/452 ; C07K 1/4475 ; A61K 3/9385 ;
U.S. Cl.
CPC ...
C07K 1/4525 ; C07K 1/452 ; C07K 1/4475 ; A61K 3/9385 ;
Abstract
A novel cytokine, designated Apo-2 ligand, which induces mammalian cancer cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to Apo-2 ligand are also provided. Methods of using Apo-2 ligand to induce apoptosis and to treat pathological conditions such as cancer, are further provided.