The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 25, 2004
Filed:
Mar. 23, 2000
John M. Davis, Chicago, IL (US);
Doncho P. Uzunov, Chicago, IL (US);
Other;
Abstract
A method of screening for non-steroidal neuropsychiatric agents includes determining the ability of a candidate non-steroidal agent to selectively regulate or alter the central nervous system content and/or bioavailability of an endogenous neuroactive steroid. In particular, the method includes determining the ability of the agent to selectively regulate a rate-limiting step in the bio-control of the bioavailable amount of an endogenous neuroactive steroid, wherein the rate-limiting step may be either a step in biosynthesis of an endogenous neuroactive steroid, such as allopregnanolone, or a step in the biodegradation of such an endogenous neuroactive steroid. Alternatively, the method may include determining the ability of a candidate agent in selectively regulating the rate of reuptake of an endogenous neuroactive steroid by neurons or glial cells.