The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 04, 2004
Filed:
Feb. 05, 2003
Vitalij K. Pecharsky, Ames, IA (US);
Viktor P. Balema, Ames, IA (US);
Jerzy W. Wiench, Ames, IA (US);
Marek Pruski, Ames, IA (US);
Iowa State University Research Foundation, Inc., Ames, IA (US);
Abstract
The present invention provides a method of preparing a phosphonium salt of the formula [R R R P—CR R R ]X, comprising ball-milling a phosphine of the formula R R R P with a compound of the formula XCR R R ; a method of preparing a phosphorus ylide of the formula R R R P═CR R , comprising ball-milling a phosphonium salt of the formula [R R R P—HCR R ]X in the presence of a base; and a method of preparing an olefin of the formula R R C═CR H or R R C═CR R , comprising ball-milling a phosphorus ylide of the formula R R R P═CR R with a compound of the formula R C(O)H or R C(O)R . The inventive method produces phosphonium salts and phosphorus ylides by mechanical processing solid reagents under solvent-free conditions. The advantages of the present invention over conventional solution methods, include: (1) extremely high selectivity; (2) high yields; (3) low processing temperatures; (4) simple and scalable reactions using commercially available equipment; and (5) the complete elimination of solvents from the reaction.