The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 04, 2004
Filed:
Apr. 08, 2002
Applicant:
Inventors:
Frank Breitling, Heidelberg, DE;
Melvyn Little, Neckargemund, DE;
Stefan Dübel, Dossenheim, DE;
Michael Braunagel, Oslo, NO;
Iris Klewinghaus, Mannheim, DE;
Assignee:
Deutsches Krebsforschungszentrum Stiftung des offentlichen Rechts, Heidelburg, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 ; C12N 1/562 ; C12N 1/566 ; C12N 1/570 ; C12P 2/102 ; G01N 3/353 ;
U.S. Cl.
CPC ...
C12Q 1/68 ; C12N 1/562 ; C12N 1/566 ; C12N 1/570 ; C12P 2/102 ; G01N 3/353 ;
Abstract
A phagemid has been constructed that expresses an antibody fused to coliphage pIII protein. The phagemid is suitable for selecting specific antibodies from large gene libraries with small quantities of antigen. The antibody-pIII gene can be strongly repressed, so that it allows antibody libraries to be amplified without the danger of deletion mutants predominating. After induction, large quantities of the fusion protein may be expressed.