The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 04, 2004
Filed:
Jun. 28, 2001
Applicant:
Inventors:
Jack L. Leonard, Shrewsbury, MA (US);
Alan P. Farwell, West Boylston, MA (US);
Assignee:
University of Massachusetts, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 3/350 ;
U.S. Cl.
CPC ...
G01N 3/350 ;
Abstract
Truncated thyroid hormone receptors &Dgr;TR&agr;1 and &Dgr;TR&agr;2 have been discovered to play a role in actin-based endocytosis, e.g., in the nervous system. The invention relates to methods of discovering ligands effective in modulating endocytosis and transgenic mice with altered expression of &Dgr;TR&agr;1 and &Dgr;TR&agr;2. The invention is useful for the discovery and testing of compounds for treating disorders of the nervous system such as depression.