Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors

Abstract

Substituted heteroaromatic compounds of formula (I), wherein X is N or CH; Y is CR and V is N; or Y is N and V is CR ; or Y is CR and V is CR ; or Y is CR and V is CR ; R represents a group CH SO CH CH NHCH —Ar—, wherein Ar is selected from phenyl, furan, thiophene, pyrrole and thiazole, each of which may optionally be substituted by one or two halo, C alkyl or C alkoxy groups; R is selected from the group comprising hydrogen, halo, hydroxy, C alkyl, C alkoxy, C alkylamino and di[C alkyl]amino; U represents a phenyl, pyridyl, 3H-imidazolyl, indolyl, isoindolyl, indolinyl, isoindolinyl, 1H-indazolyl, 2,3-dihydro-1H-indazolyl, 1H-benzimidazolyl, 2,3-dihydro-1H-benzimidazolyl or 1H-benzotriazolyl group, substituted by an R group and optionally substituted by at least one independently selected R group; R is selected from a group comprising benzyl, halo-, dihalo- and trihalobenzyl, benzoyl, pyridylmethyl, pyridylmethoxy, phenoxy, benzyloxy, halo-, dihalo- and trihalobenzyloxy and benzenesulphonyl, or R represents trihalomethylbenzyl or trihalomethylbenzyloxy; or R represents a group of formula (a) wherein each R is independently selected from halogen, C alkyl, C alkoxy; and n is 0 to 3; each R is independently hydroxy, halogen, C alkyl, C alkenyl, C alkynyl, C alkoxy, amino, C alkylamino, di[C alkyl]amino, C alkylthio, C alkylsulphinyl, C alkylsulphonyl, C alkylcarbonyl, carboxy, carbamoyl, C alkoxycarbonyl, C alkanoylamino, N-(C alkyl)carbamoyl, N,N-di(C alkyl)carbamoyl, cyano, nitro and trifluoromethyl; and salts and solvates thereof, are disclosed, as are methods for their preparation, pharmaceutical compositions containing them and their use in medicine.