The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 20, 2004
Filed:
Sep. 29, 1999
Mark Edward Bunnage, Sandwich, GB;
John Paul Mathias, Sandwich, GB;
Stephen Derek Albert Street, Sandwich, GB;
Anthony Wood, Sandwich, GB;
Pfizer Inc, New York, NY (US);
Abstract
Compounds of formulae (IA) and (IB) or pharmaceutically or veterinarily acceptable salts thereof, or pharmaceutically or veterinarily acceptable solvates of either entity, wherein R is C to C alkyl substituted with C to C cycloalkyl, CONR R or a N-linked heterocyclic group; (CH ) Het or (CH ) Ar; R is C to C alkyl; R is C to C alkyl optionally substituted with C to C alkoxy; R is SO NR R ; R and R are each independently selected from H and C to C alkyl optionally substituted with C to C alkoxy, or, together with the nitrogen atom to which they are attached, form a 5- or 6-membered heterocyclic group; R and R , together with the nitrogen atom to which they are attached, form a 4-R -piperazinyl group; R is H or C to C alkyl optionally substituted with OH, C to C alkoxy or CONH ; H is an optionally substituted C-linked 5- or 6-membered heterocyclic group; Ar is optionally substituted phenyl; and n is 0 or 1; are potent and selective cGMP PDE5 inhibitors useful in the treatment of, inter alia, male erectile dysfunction and female sexual dysfunction.