The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 20, 2004
Filed:
Jan. 06, 1999
Applicant:
Inventors:
E. Peter Greenberg, Iowa City, IA (US);
John E. Cronan, Jr., Urbana, IL (US);
Bryce V. Plapp, Iowa City, IA (US);
Matthew R. Parsek, Iowa City, IA (US);
Assignee:
Other;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 3/900 ; A61K 3/902 ; C12P 1/934 ; C12P 1/564 ; C12N 1/20 ;
U.S. Cl.
CPC ...
A61K 3/900 ; A61K 3/902 ; C12P 1/934 ; C12P 1/564 ; C12N 1/20 ;
Abstract
Provided are compositions and methods useful for modulating the activity of autoinducer synthase catalysts. A method for identifing modulators of the autoinducer synthesis reaction is also provided. Such modulators are useful for controlling bacterial growth and can be used for therapeutic treatment of bacterial infections particularly in immunocompromised subjects. They are also useful in treating disease states associated with autoinducer synthesis and biofilm development.