The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 13, 2004
Filed:
Jan. 07, 2003
Jean Claude Arnould, Reims, FR;
Angiogene Pharmaceuticals Limited, Oxford, GB;
Abstract
The invention related to colchinol derivatives of the formula (I): Wherein: R , R and R are each independently hydroxy, phosphoryloxy (—OPO H ), C alkoxy or an in vivo hydrolysable ester of hydroxy, with the proviso that at least 2 of R , R and R are C alkoxy; A is —CO—, —C(O)O—, —CON(R )— (wherein R is hydrogen, C alkyl, C alkoxyC alkyl, aminoC alkyl or hydroxyC alkyl); a is an integer from 1 to 4 inclusive; R and R are independently selected from hydrogen, hydroxy and amino; B is —O—, —CO—, N(R )CO—, —CON(R )—, —N(R )C(O)O—, —N(R )CON(R )—, —N(R )SO —, —SO N(R )— or a direct single blond (wherein R and R are independently selected from hydrogen, C alkyl, C alkoxyC alkyl, aminoC alkyl and hydroxyC alkyl); b is 0 or an integer from 1 to 4 inclusive, (provided that when b is 0, B is a single direct bond); D is carboxy, sulpho, tetrazolyl, imidazolyl, phosphoryloxy, hydroxy, amino, N—(C alkyl)amino, N,N-di(C alkyl)amino, or of the formula —Y (CH ) R or —NHCH(R )COOH; [wherein Y is a direct single bond, —O—, —C(O)—, —N(R )C(O)— or —C(O)N(R )— (wherein R is hydrogen, C alkyl, C alkoxyC alkyl, aminoC alkyl or hydroxyC alkyl); e is 0 or an integer from 1 to 4 inclusive.