The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 13, 2004
Filed:
Jun. 14, 2001
Applicant:
Inventors:
Steffen Nock, Redwood City, CA (US);
David S. Wilson, Hayward, CA (US);
Jiangchun Wu, Fremont, CA (US);
Assignee:
Zyomix, Inc., Hayward, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/600 ; C12P 2/106 ;
U.S. Cl.
CPC ...
C07K 1/600 ; C12P 2/106 ;
Abstract
Improved methods for making antibody fragments, preferably F(ab′) fragments from various classes and subclasses of antibodies is described. Pretreatment of antibodies with deglycosylases or cellular inhibition of glycosylation during expression, yields antibodies having improved susceptibility towards protease cleavage, preferably pepsinolysis, which yields F(ab′) antibody fragments. Compositions resulting from such methods are further disclosed.