The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 13, 2004
Filed:
Aug. 04, 2000
Applicant:
Inventors:
Cory M. Hogaboam, Ann Arbor, MI (US);
Cynthia L. Bone-Larson, Petersburg, MI (US);
Kenneth J. Simpson, Edinburgh, GB;
Nicholas W. Lukacs, Brighton, MI (US);
Steven L. Kunkel, Ann Arbor, MI (US);
Lisa M. Colletti, Webberville, MI (US);
Robert M. Strieter, Sherman Oaks, CA (US);
Assignee:
Other;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 3/820 ; A61K 3/800 ; A01N 6/300 ; A01N 2/500 ; C07K 1/700 ;
U.S. Cl.
CPC ...
A61K 3/820 ; A61K 3/800 ; A01N 6/300 ; A01N 2/500 ; C07K 1/700 ;
Abstract
Disclosed is the surprising discovery that CXC chemokines function to induce rapid hepatocyte proliferation and liver regeneration after injury. The invention thus provides a range of compositions and methods for use in treating liver injury, including those suitable for treating acetaminophen overdose outside the therapeutic window for N-acetyl-cysteine treatment, and those that limit the hepatotoxic side-effects of gene therapy regimens.