The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 06, 2004
Filed:
Nov. 15, 2001
Applicant:
Inventors:
Gloria A. Breault, Macclesfield, GB;
Stewart R. James, Macclesfield, GB;
Janet E. Pease, Macclesfield, GB;
Assignee:
AstraZeneca AB, Sodertalje, SE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 3/133 ; A61K 3/1405 ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
A61K 3/133 ; A61K 3/1405 ; C07D / ; C07D / ;
Abstract
A pyrimidine derivative of formula (I) or (I′): wherein: R is a substituent as defined within; Q is optionally substituted phenyl, and Q bears a substituent of formula (Ia) wherein: X, Y , Y , Z, n, and m are as defined within; —NQ is an optionally substituted heterocyclic moiety containing one hydrogen heteroatom and optionally containing a further heteroatom; or a pharmaceutically acceptable salt in vivo hydrolysable ester thereof; are useful as anti-cancer agents. Processes for their manufacture and pharmaceutical compositions containing them are described.