The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 2004
Filed:
Aug. 28, 2000
Craig A. Townsend, Baltimore, MD (US);
James D. Dick, Upperco, MD (US);
Gary R. Pasternack, Baltimore, MD (US);
Francis P. Kuhajda, Lutherville, MD (US);
Nicole M. Parrish, Ellicott City, MD (US);
The Johns Hopkins University School of Medicine, Baltimore, MD (US);
Abstract
This invention provides methods for treating a mycobacterial infection by administering to an animal a pharmaceutical composition containing a compound having the formula R—SO —Z—CO—Y, where R is an alkyl group having 6-20 carbons; Z is a radical selected from —CH —, —O—, and —NH—, two of these radicals coupled together, or —CH ═CH —; Y is —NH , O—CH —C H , —CO—CO—O—CH , or O—CH ; and n is 1 or 2. It has been discovered that these compounds inhibit growth of microbial cells which synthesize &agr;-substitued, &bgr;-hydroxy fatty acids, particularly corynemycolic acid, nocardic acid, and mycolic acid. These compounds may be used to inhibit growth of mycobacterial cells, such as drug-resistant and