The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 2004
Filed:
Jun. 04, 2001
Applicant:
Inventors:
Nnochiri N. Ekwuribe, Cary, NC (US);
Christopher H. Price, Chapel Hill, NC (US);
Aslam M. Ansari, Rockville, MD (US);
Amy L. Odenbaugh, Morrisville, NC (US);
Assignee:
Nobex Corporation, Durham, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/823 ; C07C 4/311 ; C07K 1/4585 ; C08G 6/354 ;
U.S. Cl.
CPC ...
A61K 3/823 ; C07C 4/311 ; C07K 1/4585 ; C08G 6/354 ;
Abstract
A mixture of conjugates in which each conjugate in the mixture comprises a calcitonin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may lower serum calcium levels in a subject by 10, 15 or even 20 percent or more. Moreover, the mixture may be more effective at surviving an in vitro model of intestinal digestion than non-conjugated calcitonin. Furthermore, the mixture may exhibit a higher bioavailability than non-conjugated calcitonin.