The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 30, 2004
Filed:
Nov. 26, 2001
Applicant:
Inventor:
J. Michael Schiff, Menlo Park, CA (US);
Assignee:
Geron Corporation, Menlo Park, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 6/300 ; C12N 1/500 ; C12N 1/563 ; C12N 5/00 ; C07H 2/104 ;
U.S. Cl.
CPC ...
A01N 6/300 ; C12N 1/500 ; C12N 1/563 ; C12N 5/00 ; C07H 2/104 ;
Abstract
This disclosure provides a system for specifically killing cancer cells which can be used in the course of human therapy. Vectors of the invention comprise an encoding sequence for a glycosyltransferase, under control of a tumor or tissue specific transcriptional control element, such as the promoter for telomerase reverse transcriptase. Exemplary glycosyltransferases are the A or B transferase enzymes, which cause the cancer cells to express ABO histo blood group allotypes against which humans have naturally occurring antibody. This provides for ongoing surveillance for newly emerging cells with a malignant phenotype.