The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 23, 2004

Filed:

Nov. 26, 2002
Applicant:
Inventors:

Rajashree Joshi-Hangal, Union City, CA (US);

Joseph Rubinfeld, Danville, CA (US);

Sanjeev Redkar, Union City, CA (US);

Ashok Y. Gore, San Ramon, CA (US);

Assignee:

SuperGen, Inc., Dublin, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 5/116 ;
U.S. Cl.
CPC ...
C07C 5/116 ;
Abstract

A method is provided for preparing a pharmaceutical composition comprising: taking polyoxyethylated castor oil which if diluted 1:10 in water has a pH greater than 5 and aging the polyoxyethylated castor oil by exposing the polyoxyethylated castor oil to a gas comprising oxygen for a period of time, the exposure to the gas over the period of time causing an acidity of the polyoxyethylated castor oil to increase; and forming a pharmaceutical composition comprising the aged polyoxyethylated castor oil and a pharmaceutically active agent such as paclitaxel; wherein at least 80% of the potency of the pharmaceutically active agent is retained by the pharmaceutical composition after the pharmaceutical composition is stored for at least 7 days at 40° C.


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