The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 23, 2004
Filed:
Nov. 03, 1998
Applicant:
Inventors:
Tom Tsang, Tucson, AZ (US);
Eugene W. Gerner, Tucson, AZ (US);
David T. Harris, Tucson, AZ (US);
Evan Hersh, Tucson, AZ (US);
Assignee:
The Arizona Board of Regents on behalf of The University of Arizona, Tucson, AZ (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/585 ; C12N 1/586 ; A61K 4/800 ;
U.S. Cl.
CPC ...
C12N 1/585 ; C12N 1/586 ; A61K 4/800 ;
Abstract
Methods and compositions are provided for transgene expression in target cells. Expression constructs using an inducible amplification system to drive expression of a therapeutic gene or other gene of interest in mammalian host cells are provided, as well as methods therefor. Inducible expression of the transgenes at high levels under physiologic conditions results from induction by hyperthermic conditions relative to the basal temperature of the host cells.